Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 17/20 | 0.58 |
| ▸ | DLK1 | P80370 | 1/20 | 0.53 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.53 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.51 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.51 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910152 | 0.93 | MAP3K12 (0.57) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL15602532 | 0.91 | MAP3K12 (0.65) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL16568637 | 0.91 | MAP3K12 (0.65) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL15602613 | 0.90 | MAP3K12 (0.58) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL16568686 | 0.90 | MAP3K12 (0.58) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL19910124 | 0.89 | MAP3K12 (0.68) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL15602526 | 0.89 | MAP3K12 (0.68) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| Hydrochloric Acid SCHEMBL16568353 | 0.89 | MAP3K12 (0.57) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL16573753 | 0.89 | MAP3K12 (0.77) | MAP3K12DLK1DRG1MAP3K13MAPK8 | |
| SCHEMBL15602436 | 0.89 | MAP3K12 (0.77) | MAP3K12DLK1DRG1MAP3K13MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | PDXK, PRMT1, DMPK | MAP3K12 367/4885DLK1 24/4885DRG1 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.