Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657760 | 1.00 | CNR1 (0.47) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1656476 | 0.94 | CNR1 (0.47) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1656478 | 0.94 | CNR1 (0.47) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1655340 | 0.93 | CNR1 (0.52) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1655338 | 0.93 | CNR1 (0.52) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1657874 | 0.91 | CNR1 (0.50) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1655790 | 0.91 | CNR1 (0.50) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1657876 | 0.91 | CNR1 (0.50) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1655791 | 0.91 | CNR1 (0.50) | CNR1ALDH1A1CNR2SREBF2FAAH | |
| SCHEMBL1655789 | 0.90 | CNR1 (0.49) | CNR1ALDH1A1CNR2SREBF2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082156-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. | 2011-04-07 | — | — | US | claimed |
| EP-3210972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | Catabasis Pharmaceuticals, Inc. (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20150344430-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2015-12-03 | — | — | US | disclosed |
| WO-2011044136-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2011-04-14 | — | — | WO | disclosed |
| WO-2011044136-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20110082156-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. | 2011-04-07 | — | — | US | disclosed |
| US-20110082156-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344430-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | CNR1 2881/4885ALDH1A1 3440/4885CNR2 2509/4885 |
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | CNR1 2881/4885ALDH1A1 3440/4885CNR2 2509/4885 |
| US-20110082156-A1 | FATTY ACID ACIPIMOX DERIVATIVES AND THEIR USES | ACOX3, ACOX1, PAOX | CNR1 1266/4885ALDH1A1 1335/4885CNR2 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.