Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571057 | 0.86 | PARP1 (0.39) | PARP1XDHSLC22A12PARP2MAP4K4 | |
| SCHEMBL16571716 | 0.86 | MAP2 (0.43) | PARP1XDHSLC22A12CCNCCDK8 | |
| SCHEMBL16571390 | 0.85 | CCNC (0.47) | XDHSLC22A12CCNCCDK8CASP1 | |
| SCHEMBL16571180 | 0.84 | SLC22A12 (0.42) | PARP1XDHSLC22A12CCNCCDK8 | |
| SCHEMBL19478347 | 0.84 | PARP1 (0.37) | PARP1XDHSLC22A12CCNCCDK8 | |
| SCHEMBL16571539 | 0.83 | CCNC (0.35) | CCNCCDK8NUDT1JAK2TGFBR1 | |
| SCHEMBL19478319 | 0.82 | CCNC (0.39) | PARP1XDHCCNCCDK8EGLN1 | |
| SCHEMBL19478363 | 0.82 | SCN9A (0.41) | PARP1XDHSLC22A12CCNCCDK8 | |
| SCHEMBL16571181 | 0.81 | CCNC (0.51) | XDHSLC22A12CCNCCDK8SCN9A | |
| SCHEMBL16571739 | 0.81 | XDH (0.40) | PARP1XDHSLC22A12SCN9ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |