Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19384786 | 0.95 | HPGD (0.47) | PLK1AKT1CA1CA2HPGD | |
| SCHEMBL19384704 | 0.95 | HPGD (0.47) | PLK1AKT1CA1CA2HPGD | |
| SCHEMBL21632675 | 0.93 | AKT1 (0.44) | PLK1AKT1CA1CA2MGLL | |
| SCHEMBL25133970 | 0.91 | PLK1 (0.46) | PLK1AKT1CA1CA2HPGD | |
| SCHEMBL19678216 | 0.90 | PLK1 (0.44) | PLK1AKT1CA1CA2MGLL | |
| SCHEMBL22510595 | 0.90 | PLK1 (0.44) | PLK1AKT1CA1CA2MGLL | |
| SCHEMBL25328439 | 0.90 | TLR2 (0.42) | PLK1AKT1HPGDHTTSMN1; SMN2 | |
| SCHEMBL21989802 | 0.90 | TLR2 (0.42) | PLK1AKT1HPGDHTTSMN1; SMN2 | |
| SCHEMBL12617467 | 0.88 | MGLL (0.54) | AKT1CA1CA2MGLLADORA1 | |
| SCHEMBL30756675 | 0.88 | MGLL (0.54) | AKT1CA1CA2MGLLADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3868409-B1 | THIOPHENOL-MALEIMIDE AND BROM-MALEIMIDE DERIVATIVES AS LINKER FOR ANTIBODY-DRUG CONJUGATES (ADC) FOR TREATING TUMORS | REMEGEN CO LTD (CN) | 2024-07-17 | — | — | EP | disclosed |
| WO-2020125546-A1 | CONNECTOR FOR USE IN ANTIBODY MEDICAMENT CONJUGATE AND APPLICATIONS OF CONNECTOR | 荣昌生物制药（烟台）有限公司 | 2020-06-25 | — | — | WO | disclosed |
| WO-2015038426-A1 | SELF-IMMOLATIVE LINKERS CONTAINING MANDELIC ACID DERIVATIVES, DRUG-LIGAND CONJUGATES FOR TARGETED THERAPIES AND USES THEREOF | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | disclosed |