Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658291 | 1.00 | ESR1 (0.35) | ESR1ESR2HTR6OPRM1SLC9A1 | |
| SCHEMBL1657966 | 0.82 | OPRM1 (0.33) | HTR6OPRM1NPC1PKM | |
| SCHEMBL1657970 | 0.82 | OPRM1 (0.33) | HTR6OPRM1NPC1PKM | |
| SCHEMBL1657108 | 0.81 | ESR1 (0.36) | ESR1ESR2HTR6 | |
| SCHEMBL1657106 | 0.81 | ESR1 (0.36) | ESR1ESR2HTR6 | |
| SCHEMBL5725880 | 0.71 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL5726740 | 0.70 | ESR2 (0.42) | ESR1ESR2 | |
| SCHEMBL5582354 | 0.70 | ESR1 (0.43) | ESR1ESR2HTR6OPRM1SLC9A1 | |
| SCHEMBL5726168 | 0.69 | ESR2 (0.44) | ESR1ESR2 | |
| SCHEMBL5725365 | 0.68 | ESR2 (0.45) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943224-B1 | ESTROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7923568-B2 | Estrogen receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-04-12 | — | — | US | disclosed |
| US-20100168188-A1 | Estrogen Receptor Modulators | MERCK SHARP & DOHME LLC | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168188-A1 | Estrogen Receptor Modulators | ESR2, GPER1, ESRRA | ESR1 5/4885ESR2 1/4885HTR6 1529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.