Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658864 | 0.83 | ALDH1A1 (0.61) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1658801 | 0.83 | KDM4E (0.64) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1657467 | 0.83 | ALDH1A1 (0.57) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL12909290 | 0.82 | POLB (0.65) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1658238 | 0.81 | KDM4E (0.58) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1657449 | 0.81 | ALDH1A1 (0.53) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL10149736 | 0.81 | POLB (0.64) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL10149809 | 0.81 | POLB (0.64) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1658587 | 0.81 | KDM4E (0.57) | ROCK1ROCK2POLBKDM4EALDH1A1 | |
| SCHEMBL1658177 | 0.81 | ALDH1A1 (0.57) | ROCK1ROCK2POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | claimed |
| EP-2214667-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | Angion Biomedica Corp. (US) | 2010-08-11 | — | — | EP | claimed |
| WO-2009054952-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2009-04-30 | — | — | WO | claimed |
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | PARP1, PARP11, PARP2 | ROCK1 904/4885ROCK2 1184/4885POLB 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.