Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | MMP12 | P39900 | 1/20 | 0.65 |
| ▸ | MMP1 | P03956 | 7/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 6/20 | 0.48 |
| ▸ | MMP7 | P09237 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655650 | 1.00 | MMP9 (0.65) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2927653 | 0.92 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655602 | 0.91 | MMP9 (0.67) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1658416 | 0.91 | MMP9 (0.67) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656110 | 0.90 | MMP9 (0.65) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656824 | 0.90 | MMP9 (0.65) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2927874 | 0.90 | MMP9 (0.65) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656134 | 0.88 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656114 | 0.88 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655568 | 0.88 | MMP9 (0.67) | MMP9MMP2MMP12MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932389-B2 | treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis | MERCK SERONO S.A. (CH) | 2011-04-26 | — | — | US | disclosed |