Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12689727 | 0.88 | MET (0.60) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL16587110 | 0.79 | MET (0.61) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12487158 | 0.77 | MET (0.75) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12689708 | 0.77 | MET (0.60) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12689713 | 0.77 | MET (0.76) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL16587146 | 0.76 | MET (0.53) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL16587143 | 0.76 | MET (0.59) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12689730 | 0.76 | MET (0.74) | MET | |
| SCHEMBL12489807 | 0.76 | MET (0.80) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12489857 | 0.75 | MET (0.80) | METCYP2C9PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987269-B2 | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-03-24 | — | — | US | disclosed |
| US-8987269-B2 | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-03-24 | — | — | US | disclosed |