Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16587287 | 0.92 | NPC1 (0.42) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452576 | 0.89 | NPC1 (0.42) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16587446 | 0.88 | RXRA (0.46) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL16452725 | 0.87 | NR1H4 (0.43) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452588 | 0.87 | PDE4B (0.46) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452724 | 0.82 | NPC1 (0.41) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16587286 | 0.82 | NPC1 (0.43) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452552 | 0.81 | NPC1 (0.44) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452732 | 0.81 | TP53 (0.43) | HAVCR2NPC1RAB9AHSD17B10TSHR | |
| SCHEMBL16452512 | 0.81 | NPC1 (0.43) | HAVCR2NPC1RAB9AHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987318-B2 | Liver X receptor (LXR) modulators for the treatment of dermal diseases, disorders and conditions | ALEXAR THERAPEUTICS, INC. (US) | 2015-03-24 | — | — | US | disclosed |