Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | LCAT | P04180 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472383 | 0.85 | AR (0.38) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL16472307 | 0.81 | KCNH2 (0.35) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL16587754 | 0.81 | KCNH2 (0.35) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL16587773 | 0.79 | GPR119 (0.39) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL12683397 | 0.72 | CHRM2 (0.42) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL16478727 | 0.72 | CHRM2 (0.42) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL12683336 | 0.71 | CHRM2 (0.40) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL22229899 | 0.71 | SMN1; SMN2 (0.54) | AR | |
| SCHEMBL16472305 | 0.70 | GPR119 (0.40) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL12683565 | 0.69 | CSNK1A1 (0.39) | ARJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |