Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277300 | 0.88 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3279504 | 0.88 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3277307 | 0.88 | SLC7A5 (0.60) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL11298542 | 0.87 | SLC7A5 (0.55) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL11298546 | 0.87 | SLC7A5 (0.55) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL30705337 | 0.84 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3730019 | 0.84 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL16070908 | 0.84 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL2328752 | 0.82 | SLC7A5 (0.57) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL5321753 | 0.82 | SLC7A5 (0.71) | SLC7A5PTGS1KDM4EUSP2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |