Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298542 | 1.00 | SLC7A5 (0.55) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL16587782 | 0.87 | SLC7A5 (0.58) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL30705337 | 0.82 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3730019 | 0.82 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL16070908 | 0.82 | SLC7A5 (0.64) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL180009 | 0.79 | SLC7A5 (0.75) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL29405664 | 0.79 | SLC7A5 (0.75) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL180010 | 0.79 | SLC7A5 (0.75) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL16826246 | 0.79 | SLC7A5 (0.75) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL29622702 | 0.79 | SLC7A5 (0.75) | SLC7A5PTGS1KDM4EUSP2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | claimed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | claimed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | claimed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | claimed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | claimed |
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | disclosed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | MICA, VIP, NPEPPS | SLC7A5 964/4885PTGS1 3813/4885KDM4E 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.