Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323124 | 0.81 | KDR (0.48) | MAPTSMN1; SMN2CHRM3JAK1FYN | |
| SCHEMBL3323936 | 0.70 | KDR (0.53) | FYN | |
| SCHEMBL3323046 | 0.69 | KDR (0.48) | SMN1; SMN2MOKJAK1FYNKCNH2 | |
| SCHEMBL17754101 | 0.69 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2CHRM3NOS1 | |
| SCHEMBL30577399 | 0.69 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2CHRM3NOS1 | |
| SCHEMBL3324045 | 0.69 | KDR (0.47) | MOKJAK1FYN | |
| SCHEMBL3326947 | 0.68 | KDR (0.52) | PARP1JAK1AOC3USP7 | |
| SCHEMBL13363814 | 0.66 | KDR (0.50) | PARP1JAK1NOS1AOC3USP7 | |
| SCHEMBL29864585 | 0.65 | NCF1 (0.61) | SMN1; SMN2PARP1NOS1ABL1KCNH2 | |
| SCHEMBL4164833 | 0.65 | NCF1 (0.61) | SMN1; SMN2PARP1NOS1ABL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114941-B1 | BICYCLIC HETEROCYCLIC COMPOUNDS AS FGFR INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2015-03-25 | — | — | EP | disclosed |