Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | BRAF | P15056 | 7/20 | 0.57 |
| ▸ | EGFR | P00533 | 6/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 5/20 | 0.53 |
| ▸ | CSF1R | P07333 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226738 | 0.92 | RAD52 (0.82) | RAD52BRAFEGFRDDR1 | |
| SCHEMBL19986863 | 0.86 | RAD52 (0.71) | RAD52BRAFEGFRABL1DDR1 | |
| SCHEMBL19986849 | 0.86 | RAD52 (0.81) | RAD52DDR1 | |
| SCHEMBL17208696 | 0.85 | RAD52 (0.80) | RAD52DDR1 | |
| SCHEMBL17208720 | 0.85 | RAD52 (0.95) | RAD52DDR1 | |
| SCHEMBL17208642 | 0.85 | RAD52 (0.79) | RAD52ABL1DDR1KIT | |
| SCHEMBL22457642 | 0.84 | RAD52 (0.78) | RAD52DDR1 | |
| SCHEMBL2228555 | 0.84 | RAD52 (0.84) | RAD52DDR1 | |
| SCHEMBL17208643 | 0.83 | RAD52 (0.67) | RAD52BRAFEGFRABL1 | |
| SCHEMBL2280193 | 0.82 | RAD52 (0.75) | RAD52BRAFEGFRDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | disclosed |