SCHEMBL1659040

SCHEMBL1659040

CO[SiH](O[SiH3])c1ccccc1C

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
ACHE P22303 2/20 0.36
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
GAA P10253 1/20 0.31
ESR1 P03372 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA7 P43166 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30492014 0.87 TSHR (0.43) TSHRACHEMEN1KMT2ANPC1
SCHEMBL64055 0.87 TSHR (0.43) TSHRACHEMEN1KMT2ANPC1
SCHEMBL17391479 0.76 TSHR (0.33) TSHRACHE
SCHEMBL17391507 0.76 CA4 (0.38) TSHRACHE
SCHEMBL855225 0.76 TSHR (0.33) TSHRACHE
SCHEMBL27101093 0.76 TSHR (0.30) TSHRACHE
SCHEMBL17391527 0.72 TSHR (0.38) TSHRNPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL9148449 0.71 CA1 (0.38) TSHRACHERAB9ASMN1; SMN2ALDH1A1
SCHEMBL2356053 0.71 CA4 (0.35) ALDH1A1CA1CA2CA7CA9
SCHEMBL27595314 0.71 TSHR (0.41) TSHRACHEMEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8338511-B2 Thermoplastic polyester resin composition MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 2012-12-25 US disclosed
EP-2314643-B1 THERMOPLASTIC POLYESTER RESIN COMPOSITION MITSUBISHI ENG PLASTICS CORP (JP) 2012-05-16 EP disclosed
US-20110184101-A1 THERMOPLASTIC POLYESTER RESIN COMPOSITION MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 2011-07-28 US disclosed
EP-2314643-A1 THERMOPLASTIC POLYESTER RESIN COMPOSITION Mitsubishi Engineering-Plastics Corporation (JP) 2011-04-27 EP disclosed