Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659170 | 1.00 | KMT2A (0.46) | KMT2AMEN1DRD2L3MBTL1ALDH1A1 | |
| SCHEMBL1659175 | 1.00 | KMT2A (0.46) | KMT2AMEN1DRD2L3MBTL1ALDH1A1 | |
| SCHEMBL11906034 | 0.88 | MEN1 (0.41) | KMT2AMEN1DRD2L3MBTL1DRD4 | |
| SCHEMBL11906036 | 0.88 | MEN1 (0.41) | KMT2AMEN1DRD2L3MBTL1DRD4 | |
| SCHEMBL11906043 | 0.88 | MEN1 (0.41) | KMT2AMEN1DRD2L3MBTL1DRD4 | |
| SCHEMBL1659510 | 0.84 | MEN1 (0.54) | KMT2AMEN1DRD2ALDH1A1DRD4 | |
| SCHEMBL1659079 | 0.75 | MEN1 (0.54) | KMT2AMEN1DRD2ALDH1A1DRD4 | |
| SCHEMBL25177674 | 0.75 | HCAR2 (0.44) | L3MBTL1ALDH1A1MAPTNPSR1GAA | |
| SCHEMBL25177675 | 0.75 | HCAR2 (0.44) | L3MBTL1ALDH1A1MAPTNPSR1GAA | |
| SCHEMBL11919640 | 0.73 | MEN1 (0.43) | KMT2AMEN1DRD2ALDH1A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488028-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |