Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660491 | 0.85 | MEN1 (0.47) | MEN1KMT2ADRD2HTR2CDRD4 | |
| SCHEMBL1659510 | 0.83 | MEN1 (0.54) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL4002380 | 0.79 | SLC18A3 (0.46) | KMT2ADRD2ALDH1A1MAPT | |
| SCHEMBL23217507 | 0.78 | HTR2A (0.43) | MEN1KMT2ADRD2HTR2CALDH1A1 | |
| SCHEMBL28001883 | 0.76 | DRD2 (0.50) | DRD2HTR2CCHRM4 | |
| SCHEMBL2637185 | 0.76 | MEN1 (0.77) | MEN1KMT2ADRD2HTR2CDRD4 | |
| SCHEMBL1659175 | 0.75 | KMT2A (0.46) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL1659170 | 0.75 | KMT2A (0.46) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL1659172 | 0.75 | KMT2A (0.46) | MEN1KMT2ADRD2DRD4ALDH1A1 | |
| SCHEMBL11919642 | 0.71 | MEN1 (0.49) | MEN1KMT2ADRD2HTR2CDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488028-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| CN-102638981-A | Substituted piperidines that increase p53 activity and uses thereof | SCHERING CORP | 2012-08-15 | — | — | CN | disclosed |
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |