Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 8/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952880 | 0.87 | JAK1 (0.36) | JAK2JAK1ROCK2ROCK1CDC42BPB | |
| SCHEMBL1952848 | 0.86 | JAK1 (0.47) | JAK2JAK1 | |
| SCHEMBL1952365 | 0.86 | NAMPT (0.39) | JAK2JAK1ROCK2ROCK1CDC42BPB | |
| SCHEMBL1705735 | 0.84 | JAK2 (0.38) | JAK2JAK1ROCK2ROCK1CDC42BPB | |
| SCHEMBL16592834 | 0.81 | JAK1 (0.37) | JAK2JAK1 | |
| SCHEMBL1706287 | 0.78 | JAK1 (0.35) | JAK2JAK1ROCK2ROCK1CDC42BPB | |
| SCHEMBL1951024 | 0.77 | PARP1 (0.38) | JAK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL1950678 | 0.75 | JAK1 (0.47) | JAK1 | |
| SCHEMBL1705696 | 0.75 | NAMPT (0.38) | JAK2JAK1ROCK2ROCK1CDC42BPB | |
| SCHEMBL1706643 | 0.72 | JAK2 (0.36) | JAK2ROCK2ROCK1CDC42BPBCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-B1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL (JP) | 2015-04-01 | — | — | EP | claimed |