Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16592905 | 0.89 | JAK1 (0.38) | JAK1BTK | |
| SCHEMBL1952848 | 0.87 | JAK1 (0.47) | JAK1BTKJAK2 | |
| SCHEMBL16592839 | 0.83 | JAK2 (0.35) | JAK1BTKJAK2CDK9 | |
| SCHEMBL16592872 | 0.81 | JAK2 (0.35) | JAK1JAK2 | |
| SCHEMBL16592825 | 0.79 | CDC42BPB (0.35) | JAK1BTKJAK2CDK9 | |
| SCHEMBL16592850 | 0.78 | MAPK1 (0.35) | JAK1BTKJAK2CDK9 | |
| SCHEMBL1705735 | 0.77 | JAK2 (0.38) | JAK1JAK2 | |
| SCHEMBL1950678 | 0.77 | JAK1 (0.47) | JAK1 | |
| SCHEMBL1952365 | 0.76 | NAMPT (0.39) | JAK1JAK2 | |
| SCHEMBL1953472 | 0.72 | BTK (0.46) | JAK1BTKJAK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-B1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL (JP) | 2015-04-01 | — | — | EP | claimed |