Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29273709 | 0.76 | MAPT (0.65) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL13480594 | 0.75 | PPIA (0.61) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL27817527 | 0.74 | PPIA (0.66) | PPIAKMT2AMEN1LMNA | |
| SCHEMBL29124181 | 0.73 | KMT2A (0.75) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL30735994 | 0.73 | KMT2A (0.75) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL8670897 | 0.73 | PPIA (0.58) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL29235122 | 0.71 | GAA (0.61) | MAPTLMNAMAOAMAOBCA1 | |
| SCHEMBL1007576 | 0.70 | MAPT (0.62) | PPIAMAPTKMT2AMEN1LMNA | |
| SCHEMBL16592358 | 0.70 | CA12 (0.63) | PPIAMAPTKMT2AMEN1NTRK1 | |
| SCHEMBL22873283 | 0.70 | KMT2A (0.61) | PPIAMAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042088-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP (US) | 2015-03-26 | — | — | WO | disclosed |