Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 4/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29349953 | 1.00 | MEN1 (0.54) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL12216725 | 0.99 | MEN1 (0.55) | MEN1BLMKMT2AUSP2POLB | |
| Isothiocyanate SCHEMBL28202026 | 0.98 | MEN1 (0.52) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL29356053 | 0.94 | MEN1 (0.54) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL25596330 | 0.87 | MEN1 (0.45) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL21263759 | 0.87 | MEN1 (0.56) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL29370904 | 0.86 | MEN1 (0.51) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL29442119 | 0.85 | USP2 (0.59) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL18617 | 0.85 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL30207638 | 0.85 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9766213-B2 | Innovation to assay mixing | BIO-RAD LABORATORIES, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20150090343-A1 | INNOVATION TO ASSAY MIXING | BIO-RAD LABORATORIES, INC. | 2015-04-02 | — | — | US | disclosed |