Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16596184 | 0.92 | PIK3CD (0.45) | PIK3CDNOTUMPIK3R1KDM4ENPSR1 | |
| SCHEMBL16596148 | 0.86 | NOTUM (0.48) | PIK3CDNOTUMKDM4ENPSR1FAAH | |
| SCHEMBL16596147 | 0.86 | NOTUM (0.48) | NOTUMKDM4ENPSR1PIK3CGPIK3CB | |
| SCHEMBL22237967 | 0.86 | ALDH1A1 (0.50) | PIK3CDNOTUMKDM4ENPSR1PIK3R2 | |
| SCHEMBL16596143 | 0.86 | PIK3CD (0.48) | PIK3CDPIK3R1KDM4ENPSR1PIK3R2 | |
| SCHEMBL12943784 | 0.84 | PIK3CD (0.43) | PIK3CDNOTUMPIK3R1PIK3R2PIK3CG | |
| SCHEMBL16591271 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3R1PIK3R2PIK3CGPIK3CA | |
| SCHEMBL179610 | 0.81 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3R2PIK3CGPIK3CA | |
| SCHEMBL16583965 | 0.81 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3R2PIK3CGPIK3CA | |
| SCHEMBL18885591 | 0.81 | MAPK14 (0.46) | PIK3CDNOTUMPIK3R2PIK3CGL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657007-B2 | Substituted aminopyrimidine compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2017-05-23 | — | — | US | disclosed |
| WO-2015042078-A2 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |