Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18885591 | 0.85 | MAPK14 (0.46) | PDE7APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16591281 | 0.83 | PDE7A (0.42) | PDE7APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16596822 | 0.82 | CYP1A2 (0.41) | MAPK14CYP1A2PIK3R1PIK3CAPIK3CG | |
| SCHEMBL18885583 | 0.80 | PDE7A (0.42) | PDE7APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16596148 | 0.79 | NOTUM (0.48) | CYP1A2PIK3CD | |
| SCHEMBL16596154 | 0.78 | ALDH1A1 (0.43) | CYP1A2PIK3R1PIK3CGPIK3CD | |
| SCHEMBL16596818 | 0.78 | PIK3CD (0.49) | CYP1A2PIK3R1PIK3CAPIK3CGPIK3CD | |
| SCHEMBL16596150 | 0.76 | PIK3CD (0.42) | PIK3R1PIK3CGPIK3CD | |
| SCHEMBL16596931 | 0.75 | PIK3CD (0.49) | PDE7APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16596147 | 0.74 | NOTUM (0.48) | MAPK14PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657007-B2 | Substituted aminopyrimidine compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2017-05-23 | — | — | US | disclosed |
| US-9512114-B2 | Substituted aminopyrimidine compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160318914-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2016-11-03 | — | — | US | disclosed |
| US-20150087658-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | US | disclosed |
| WO-2015042078-A2 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318914-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MYD88 | PDE7A 525/4885PDE4A 697/4885PDE4B 687/4885 |
| US-20150087658-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MYD88 | PDE7A 525/4885PDE4A 697/4885PDE4B 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.