Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338883 | 0.85 | KMT2A (0.50) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL20335469 | 0.83 | KMT2A (0.49) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL4932875 | 0.83 | HPGD (0.50) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL30392935 | 0.81 | HRH1 (0.49) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL3632544 | 0.76 | KMT2A (0.41) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL8189491 | 0.74 | KMT2A (0.42) | KMT2ACA1CA2CA9LMNA | |
| SCHEMBL12816499 | 0.73 | KMT2A (0.41) | KMT2ACA1CA2FAAHPRSS1 | |
| SCHEMBL29384157 | 0.73 | NPSR1 (0.64) | KMT2ALMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL2566376 | 0.71 | CA1 (0.31) | CA1CA2 | |
| SCHEMBL28978008 | 0.71 | SMN1; SMN2 (0.62) | KMT2AHTTSMN1; SMN2NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049396-A1 | PROCESS AND INTERMEDIATES FOR PREPARING INDANYLOXYDIHYDROBENZOFURANYL ACETIC ACID DERIVATIVES AS GPR40 AGONISTS | Boehringer Ingelheim International GmbH (DE) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015044073-A1 | PROCESS AND INTERMEDIATES FOR PREPARING INDANYLOXYDIHYDROBENZOFURANYL ACETIC ACID DERIVATIVES AS GPR40 AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-04-02 | — | — | WO | disclosed |