Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660744 | 0.88 | PDE2A (0.38) | PDE2AP2RY14SCN9APIK3CDPIK3C2B | |
| SCHEMBL14727913 | 0.86 | TRPM2 (0.37) | PDE2AP2RY14SCN9APIK3CDPIK3C2B | |
| SCHEMBL6903422 | 0.85 | PDE2A (0.34) | PDE2AP2RY14SCN9APIK3CDPIK3C2B | |
| SCHEMBL6903551 | 0.84 | PDE2A (0.36) | PDE2AP2RY14SCN9APIK3CDPIK3C2B | |
| SCHEMBL6904357 | 0.81 | SRPK1 (0.36) | PDE2ASCN9APIK3CD | |
| SCHEMBL6903557 | 0.79 | PDE2A (0.40) | PDE2AP2RY14SCN9AMAP2K4SCN10A | |
| SCHEMBL14717866 | 0.79 | PDE2A (0.39) | PDE2AP2RY14SCN9APIK3CDSCN10A | |
| SCHEMBL14718861 | 0.77 | PDE2A (0.37) | PDE2ASCN9ASCN10A | |
| SCHEMBL6902906 | 0.76 | TRPM2 (0.37) | PDE2ASCN9APIK3CDSCN10A | |
| SCHEMBL11962993 | 0.76 | PDE2A (0.40) | PDE2AP2RY14SCN9ASCN10APTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |