⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43258 | 0.75 | — | — | |
| SCHEMBL240693 | 0.75 | — | — | |
| SCHEMBL776997 | 0.72 | — | — | |
| SCHEMBL9710368 | 0.72 | CA2 (0.44) | — | |
| SCHEMBL11520685 | 0.72 | CA2 (0.42) | — | |
| SCHEMBL24593068 | 0.72 | — | — | |
| SCHEMBL1615370 | 0.72 | — | — | |
| SCHEMBL3085455 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL1291216 | 0.72 | — | — | |
| SCHEMBL2129023 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | claimed |
| JP-3068550-A | — | — | None | — | — | JP | disclosed |
| US-12503475-B2 | Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists | CENTESSA PHARMACEUTICALS (UK) LIMITED (GB) | 2025-12-23 | — | — | US | disclosed |
| US-20250289828-A1 | MEDIUM- OR MACRO-CYCLIC BENZYL-SUBSTITUTED HETEROCYCLE DERIVATIVES AND RELATED USES | CENTESSA PHARMACEUTICALS UK LTD (GB) | 2025-09-18 | — | — | US | disclosed |
| US-20250236629-A1 | MEDIUM- OR MACRO-CYCLIC BENZYL-SUBSTITUTED HETEROCYCLE DERIVATIVES AND RELATED USES | OXFORD FINANCE LLC | 2025-07-24 | — | — | US | disclosed |
| CN-118853260-A | Lubricating oil anti-emulsifying agent and preparation method and application thereof | 中山市富日印刷材料有限公司 | 2024-10-29 | — | — | CN | disclosed |
| US-20230271973-A1 | BICYCLIC-HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS | CENTESSA PHARMACEUTICALS (OREXIA) LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| US-20230271973-A1 | BICYCLIC-HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS | CENTESSA PHARMACEUTICALS (OREXIA) LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| US-20230271973-A1 | BICYCLIC-HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS | CENTESSA PHARMACEUTICALS (OREXIA) LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| CN-116583502-A | Bicyclic-heterocyclic derivatives and their use as orexin-2 receptor agonists | 欧瑞夏治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-112701354-A | Electrolyte of lithium-sulfur battery and preparation method and application thereof | 广东邦普循环科技有限公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-101801949-B | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |
| EP-2440527-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | Topo Target A/S (DK) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142735-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | TOPOTARGET A/S (DK) | 2010-12-16 | — | — | WO | disclosed |
| CN-101516850-A | Heteroaryl compounds useful as inhibitors of E1 activating enzyme | MILLENNIUM PHARM INC (US) | 2009-08-26 | — | — | CN | disclosed |
| JP-H0368550-A | FLUORINE-CONTAINING SULFONAMIDE DERIVATIVE AND INSECTICIDE AND ACARICIDE | CENTRAL GLASS CO LTD | 1991-03-25 | — | — | JP | disclosed |