Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112344 | 0.84 | NAMPT (0.38) | NAMPTALDH1A1CYP1A2HSD17B10GABRD | |
| Hydrochloric Acid SCHEMBL2437534 | 0.82 | NAMPT (0.38) | NAMPTALDH1A1CYP1A2HSD17B10GABRD | |
| SCHEMBL22358962 | 0.82 | NAMPT (0.38) | NAMPTALDH1A1CYP1A2HSD17B10GABRD | |
| SCHEMBL994307 | 0.82 | USP2 (0.47) | ALDH1A1CYP1A2HSD17B10CYP2D6 | |
| Hydrochloric Acid SCHEMBL29172907 | 0.80 | USP2 (0.46) | ALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL20669147 | 0.77 | POLB (0.56) | NAMPTALDH1A1CYP1A2HSD17B10GABRD | |
| SCHEMBL20669191 | 0.77 | CHRNB2 (0.57) | ALDH1A1 | |
| SCHEMBL26854533 | 0.77 | CHRNB2 (0.44) | NAMPTALDH1A1CYP1A2 | |
| SCHEMBL14804556 | 0.77 | EPHX2 (0.40) | NAMPTALDH1A1CYP1A2HSD17B10GABRD | |
| SCHEMBL16058241 | 0.77 | CYP2C9 (0.56) | ALDH1A1CYP1A2HSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196369-B2 | Spirocyclic EBI2 modulators | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-02-05 | — | — | US | disclosed |
| US-20160176875-A1 | SPIROCYCLIC EBI2 MODULATORS | Sanford Burnham Prebys Medical Discovery Institute | 2016-06-23 | — | — | US | disclosed |
| WO-2015048567-A1 | SPIROCYCLIC EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176875-A1 | SPIROCYCLIC EBI2 MODULATORS | HAVCR2, BIRC2, ESR2 | CA2 2954/4885CHKA 932/4885NAMPT 3687/4885 |
| US-10196369-B2 | Spirocyclic EBI2 modulators | HAVCR2, BIRC2, ESR2 | CA2 2954/4885CHKA 932/4885NAMPT 3687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.