Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920965 | 0.76 | CRBN (0.48) | CRBNKDM4EGAAPOLB | |
| SCHEMBL20417911 | 0.76 | NEK2 (0.41) | CYP1A2CRBNKDM4EGAAPOLB | |
| SCHEMBL16600198 | 0.73 | CYP11B1 (0.41) | CRBNMEN1KMT2A | |
| SCHEMBL16600340 | 0.73 | CRBN (0.43) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL13459880 | 0.71 | OR51E2 (0.46) | CRBNKDM4EGAAPOLB | |
| SCHEMBL516011 | 0.71 | OR51E2 (0.46) | CRBNKDM4EGAAPOLB | |
| SCHEMBL16862251 | 0.70 | CYP1A2 (0.37) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL16600406 | 0.70 | ESR2 (0.33) | CYP2D6MEN1KMT2A | |
| SCHEMBL16600611 | 0.67 | CRBN (0.32) | CRBN | |
| SCHEMBL5005151 | 0.66 | KMT2A (0.56) | KDM4EGAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049405-A1 | AUTOTAXIN INHIBITOR COMPOUNDS | Pharmakea Inc. (US) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015048301-A1 | AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-04-02 | — | — | WO | disclosed |