Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.44 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459880 | 1.00 | OR51E2 (0.46) | OR51E2CRBNFKBP5KDM4EGAA | |
| SCHEMBL6920965 | 0.89 | CRBN (0.48) | OR51E2CRBNFKBP5KDM4EGAA | |
| SCHEMBL16600340 | 0.84 | CRBN (0.43) | OR51E2CRBNFKBP5 | |
| SCHEMBL9986841 | 0.81 | OR51E2 (0.34) | OR51E2CRBNFKBP5GAA | |
| SCHEMBL20633689 | 0.80 | OR51E2 (0.37) | OR51E2CRBNFKBP5GAA | |
| SCHEMBL9210113 | 0.80 | CRBN (0.38) | OR51E2CRBNFKBP5 | |
| SCHEMBL6560160 | 0.77 | OR51E2 (0.39) | OR51E2CRBNFKBP5GAA | |
| SCHEMBL20417911 | 0.76 | NEK2 (0.41) | OR51E2CRBNFKBP5KDM4EGAA | |
| SCHEMBL24242233 | 0.71 | CRBN (0.47) | OR51E2CRBNFKBP5KDM4EGAA | |
| SCHEMBL11821175 | 0.71 | NPC1 (0.39) | OR51E2CRBNFKBP5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| US-20140024635-A1 | INHIBITORS OF THE INFLUENZA A VIRUS M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-01-23 | — | — | US | disclosed |
| US-20140024635-A1 | INHIBITORS OF THE INFLUENZA A VIRUS M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-01-23 | — | — | US | disclosed |
| US-20140024635-A1 | INHIBITORS OF THE INFLUENZA A VIRUS M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-01-23 | — | — | US | disclosed |
| US-8569284-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569284-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569284-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120028957-A1 | Inhibitors Of The Influenza A Virus M2 Proton Channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2012-02-02 | — | — | US | disclosed |
| US-20120028957-A1 | Inhibitors Of The Influenza A Virus M2 Proton Channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2012-02-02 | — | — | US | disclosed |
| US-20120028957-A1 | Inhibitors Of The Influenza A Virus M2 Proton Channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028957-A1 | Inhibitors Of The Influenza A Virus M2 Proton Channel | HVCN1, ATP6AP1, ASIC1 | OR51E2 2094/4885CRBN 4372/4885FKBP5 2666/4885 |
| US-20140024635-A1 | INHIBITORS OF THE INFLUENZA A VIRUS M2 PROTON CHANNEL | HVCN1, ATP6AP1, ASIC1 | OR51E2 2094/4885CRBN 4372/4885FKBP5 2666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.