Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 18/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17943013 | 0.99 | ENPP2 (0.65) | ENPP2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL16614305 | 0.96 | ENPP2 (0.69) | ENPP2HDAC1HDAC6 | |
| SCHEMBL16600666 | 0.92 | ENPP2 (0.65) | ENPP2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL16600615 | 0.92 | ENPP2 (0.73) | ENPP2 | |
| SCHEMBL16600499 | 0.90 | ENPP2 (0.77) | ENPP2 | |
| SCHEMBL17943012 | 0.90 | ENPP2 (0.58) | ENPP2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL16614288 | 0.90 | ENPP2 (0.61) | ENPP2HDAC1HDAC8HDAC6 | |
| SCHEMBL17940600 | 0.89 | ENPP2 (0.69) | ENPP2HDAC1HDAC8HDAC6 | |
| SCHEMBL16614270 | 0.89 | ENPP2 (0.78) | ENPP2 | |
| SCHEMBL16600319 | 0.88 | ENPP2 (0.81) | ENPP2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049405-A1 | AUTOTAXIN INHIBITOR COMPOUNDS | Pharmakea Inc. (US) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015048301-A1 | AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-04-02 | — | — | WO | disclosed |