Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 17/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16600764 | 1.00 | GRIN2B (1.00) | GRIN2BPKMMAPK1KDM4ETDP1 | |
| SCHEMBL16600767 | 1.00 | GRIN2B (1.00) | GRIN2BPKMMAPK1KDM4ETDP1 | |
| SCHEMBL16600887 | 0.89 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16600891 | 0.89 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16600889 | 0.89 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL20548403 | 0.85 | GRIN2B (0.74) | GRIN2B | |
| SCHEMBL20548404 | 0.85 | GRIN2B (0.74) | GRIN2B | |
| SCHEMBL16989057 | 0.83 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16601357 | 0.83 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16989055 | 0.83 | GRIN2B (1.00) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036221-B1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | CADENT THERAPEUTICS INC (US) | 2018-11-07 | — | — | EP | claimed |
| US-10052306-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | CADENT THERAPEUTICS, INC. (US) | 2018-08-21 | — | — | US | claimed |
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | LUC THERAPEUTICS, INC. | 2017-03-16 | — | — | US | claimed |
| US-9540324-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | LUC THERAPEUTICS, INC. (US) | 2017-01-10 | — | — | US | claimed |
| US-20150225342-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | claimed |
| US-12161624-B2 | Selective octahydro-cyclopenta[c]pyrrole negative modulators of NR2B | NOVARTIS AG (CH) | 2024-12-10 | — | — | US | disclosed |
| US-20230012073-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | CADENT THERAPEUTICS, INC. (US) | 2023-01-12 | — | — | US | disclosed |
| US-11116749-B2 | Selective octahydro-cyclopenta[c]pyrrole negative modulators of NR2B | CADENT THERAPEUTICS, INC (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3461827-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | Cadent Therapeutics, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20180325868-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | CADENT THERAPEUTICS, INC. (US) | 2018-11-15 | — | — | US | disclosed |
| EP-3036221-B1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | CADENT THERAPEUTICS INC (US) | 2018-11-07 | — | — | EP | disclosed |
| US-10052306-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | CADENT THERAPEUTICS, INC. (US) | 2018-08-21 | — | — | US | disclosed |
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | LUC THERAPEUTICS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-9540324-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | LUC THERAPEUTICS, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| EP-3036221-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | Luc Therapeutics, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| US-20150225342-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| WO-2015048507-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10052306-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-20170071906-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-20150225342-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-20230012073-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-11116749-B2 | Selective octahydro-cyclopenta[c]pyrrole negative modulators of NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-12161624-B2 | Selective octahydro-cyclopenta[c]pyrrole negative modulators of NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
| US-20180325868-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885PKM 3198/4885MAPK1 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.