Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MIF | P14174 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16250472 | 0.88 | HPGD (0.64) | HPGDMIFL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5302441 | 0.87 | MIF (0.63) | MIFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14564389 | 0.83 | MIF (0.56) | MIFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4411794 | 0.82 | HPGD (0.64) | HPGDSMN1; SMN2MAPK1TP53MEN1 | |
| SCHEMBL4413144 | 0.82 | HPGD (0.64) | HPGDMIFSMN1; SMN2MAPK1TP53 | |
| SCHEMBL4414360 | 0.82 | HPGD (0.64) | HPGDCYP3A4TP53MEN1KMT2A | |
| SCHEMBL13340920 | 0.82 | HPGD (0.59) | HPGDSMN1; SMN2MAPK1TP53MEN1 | |
| SCHEMBL4413088 | 0.82 | HPGD (0.59) | HPGDSMN1; SMN2TP53KMT2A | |
| SCHEMBL13367743 | 0.80 | MIF (0.66) | MIFL3MBTL1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4414345 | 0.78 | HPGD (1.00) | HPGDMIFSMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |