SCHEMBL4413088

SCHEMBL4413088

COc1ccc2c(c1)oc(=O)n2CC(N)=O

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.59
CDYL2 Q8N8U2 10/20 0.56
CDYL Q9Y232 10/20 0.56
CBX7 O95931 9/20 0.56
CDY1; CDY1B Q9Y6F8 8/20 0.56
TP53 P04637 3/20 0.55
LMNA P02545 1/20 0.55
KMO O15229 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.52
RECQL P46063 1/20 0.52
MET P08581 1/20 0.49
POLB P06746 2/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29958210 0.89 CDYL2 (0.69) HPGDCDYL2CDYLCBX7CDY1; CDY1B
SCHEMBL27033393 0.89 CDYL2 (0.69) HPGDCDYL2CDYLCBX7CDY1; CDY1B
SCHEMBL4242148 0.88 KMO (0.61) CDYL2CDYLCBX7CDY1; CDY1BTP53
SCHEMBL13140318 0.86 TP53 (0.58) HPGDCDYL2CDYLCBX7CDY1; CDY1B
SCHEMBL3074930 0.83 TP53 (0.66) CDYL2CDYLCBX7CDY1; CDY1BTP53
SCHEMBL16601597 0.82 HPGD (0.64) HPGDTP53SMN1; SMN2KMT2A
SCHEMBL8798927 0.81 MET (0.57) HPGDCDYL2CDYLCDY1; CDY1BTP53
Hydrochloric Acid SCHEMBL9157992 0.80 MET (0.56) HPGDCDYL2CDYLCDY1; CDY1BTP53
SCHEMBL4411794 0.79 HPGD (0.64) HPGDCDYL2CDYLCBX7CDY1; CDY1B
SCHEMBL4413144 0.79 HPGD (0.64) HPGDCDYL2CDYLCBX7CDY1; CDY1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756071-B1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB PHARMA SA (BE) 2009-08-26 EP claimed
US-20070299118-A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses UCB, S.A. (BE) 2007-12-27 US claimed
EP-1756071-A1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2007-02-28 EP claimed
WO-2005118561-A1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2005-12-15 WO claimed
US-8293775-B2 Benzoxazolone derivatives, processes for preparing them and their uses UCB PHARMA, S.A. (BE) 2012-10-23 US disclosed
EP-1756071-B1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB PHARMA SA (BE) 2009-08-26 EP disclosed
US-20070299118-A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses UCB, S.A. (BE) 2007-12-27 US disclosed
EP-1756071-A1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2007-02-28 EP disclosed
WO-2005118561-A1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2005-12-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070299118-A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses PARK7, SNCA, GABRA5 HPGD 232/4885CDYL2 2601/4885CDYL 2044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.