SCHEMBL16601661

SCHEMBL16601661

O=C1C(=O)c2cc(-c3ccc(O)cc3)ccc2-c2ccc(-c3ccc(O)cc3)cc21

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
APAF1 O14727 1/20 0.55
NPC1 O15118 1/20 0.55
LMNA P02545 1/20 0.55
MAPT P10636 1/20 0.55
THRB P10828 1/20 0.55
XBP1 P17861 1/20 0.55
PTBP1 P26599 1/20 0.55
HTT P42858 1/20 0.55
RAB9A P51151 1/20 0.55
GALK1 P51570 1/20 0.55
BLM P54132 1/20 0.55
SMAD3 P84022 1/20 0.55
ATM Q13315 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
ESR1 P03372 10/20 0.54
ESR2 Q92731 9/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601659 0.92 MEN1 (0.69) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL12112513 0.91 MEN1 (0.61) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL16601710 0.88 MEN1 (0.75) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL28914940 0.88 MEN1 (0.63) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL10936171 0.85 MEN1 (0.60) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL23111390 0.80 ESR2 (0.80) MEN1KMT2ANPC1MAPTRAB9A
SCHEMBL16601794 0.79 BACE1 (0.70) ESR1ESR2MAOAUGT1A1MAOB
SCHEMBL12553057 0.79 MEN1 (0.83) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL12553042 0.79 MEN1 (0.83) MEN1KMT2AAPAF1NPC1LMNA
SCHEMBL12553052 0.79 MEN1 (0.83) MEN1KMT2AAPAF1NPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed