Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.65 |
| ▸ | CA2 | P00918 | 7/20 | 0.65 |
| ▸ | CA9 | Q16790 | 7/20 | 0.65 |
| ▸ | CA12 | O43570 | 6/20 | 0.65 |
| ▸ | CA1 | P00915 | 6/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP14 | P50281 | 2/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TARS1 | P26639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601948 | 0.95 | MMP2 (0.62) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL10029053 | 0.85 | MMP2 (0.76) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL16601947 | 0.84 | MMP2 (0.58) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL16601949 | 0.84 | MMP2 (0.84) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL16601950 | 0.83 | MMP2 (0.57) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL570169 | 0.79 | MMP2 (1.00) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569326 | 0.78 | MMP2 (0.93) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569313 | 0.77 | MMP2 (1.00) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569540 | 0.77 | MMP2 (1.00) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569670 | 0.76 | MMP2 (1.00) | MMP2CA2CA9CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993544-B2 | Carbamoylphosphonates as inhibitors and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. (IL) | 2015-03-31 | — | — | US | disclosed |