SCHEMBL16601986

SCHEMBL16601986

O=C(O)c1ccc(N2C(=O)c3ccc4c5c(ccc(c35)C2=O)C(=O)N(c2ccccc2)C4=O)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA9 Q16790 10/20 0.77
CA12 O43570 9/20 0.77
CA1 P00915 6/20 0.77
CA2 P00918 2/20 0.77
SCN2A Q99250 1/20 0.77
L3MBTL1 Q9Y468 3/20 0.71
RXFP1 Q9HBX9 2/20 0.71
POLB P06746 3/20 0.67
KDM4E B2RXH2 3/20 0.67
RECQL P46063 2/20 0.67
CASP6 P55212 2/20 0.67
TDP1 Q9NUW8 2/20 0.67
APEX1 P27695 1/20 0.67
CTDSP1 Q9GZU7 1/20 0.67
PPARA Q07869 1/20 0.65
ALDH1A1 P00352 2/20 0.59
APOBEC3A P31941 1/20 0.59
APOBEC3G Q9HC16 1/20 0.59
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10061703 0.95 CA9 (0.73) CA9CA12CA1CA2SCN2A
SCHEMBL18201565 0.88 KDM4E (0.65) CA9CA12CA1CA2SCN2A
SCHEMBL31663432 0.87 CA9 (1.00) CA9CA12CA1CA2SCN2A
SCHEMBL481667 0.87 CA9 (1.00) CA9CA12CA1CA2SCN2A
SCHEMBL16790049 0.87 CA9 (0.63) CA9CA12CA1CA2SCN2A
SCHEMBL16521595 0.85 CA9 (0.66) CA9CA12CA1CA2SCN2A
SCHEMBL7491321 0.85 POLB (0.63) CA9CA12CA1CA2SCN2A
SCHEMBL31167971 0.85 POLB (0.63) CA9CA12CA1CA2SCN2A
SCHEMBL4582684 0.83 CA9 (1.00) CA9CA12CA1CA2SCN2A
SCHEMBL1618163 0.83 KMT2A (0.76) CA9CA12CA1CA2SCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed