Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 10/20 | 0.42 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.42 |
| ▸ | CALCA | P06881 | 2/20 | 0.41 |
| ▸ | ADM2 | Q7Z4H4 | 7/20 | 0.40 |
| ▸ | CALCB | P10092 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13253227 | 0.89 | SMN1; SMN2 (0.40) | CALCRLHPGDSMN1; SMN2 | |
| SCHEMBL16602178 | 0.82 | CALCRL (0.51) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL16602176 | 0.80 | CALCRL (0.49) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997596 | 0.79 | CALCRL (0.44) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997393 | 0.79 | CALCRL (0.49) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997646 | 0.79 | ADM2 (0.45) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997477 | 0.78 | SMN1; SMN2 (0.35) | HPGDSMN1; SMN2 | |
| SCHEMBL16602175 | 0.78 | CALCRL (0.45) | CALCRLRAMP1CALCAADM2CALCB | |
| SCHEMBL3483304 | 0.78 | CALCRL (0.43) | CALCRLRAMP1CALCAADM2CALCB | |
| SCHEMBL13997599 | 0.77 | HIF1A (0.48) | CALCRLRAMP1ADM2CALCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |