Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 10/20 | 0.43 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.42 |
| ▸ | ADM2 | Q7Z4H4 | 9/20 | 0.42 |
| ▸ | CALCB | P10092 | 8/20 | 0.42 |
| ▸ | CALCA | P06881 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997646 | 0.92 | ADM2 (0.45) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13253199 | 0.89 | ADORA2A (0.39) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL16602178 | 0.86 | CALCRL (0.51) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL16602175 | 0.85 | CALCRL (0.45) | CALCRLRAMP1ADM2CALCBCALCA | |
| SCHEMBL13997596 | 0.85 | CALCRL (0.44) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL16602184 | 0.81 | CALCRL (0.47) | CALCRLRAMP1ADM2CALCBCALCA | |
| SCHEMBL13253212 | 0.80 | CALCRL (0.38) | CALCRL | |
| SCHEMBL16602179 | 0.80 | CALCRL (0.46) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997393 | 0.80 | CALCRL (0.49) | CALCRLRAMP1ADM2CALCB | |
| SCHEMBL13997603 | 0.80 | CALCRL (0.48) | CALCRLRAMP1ADM2CALCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| WO-2008153849-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CCKBR | CALCRL 6/4885RAMP1 38/4885ADM2 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.