Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 15/20 | 0.69 |
| ▸ | FLT1 | P17948 | 3/20 | 0.69 |
| ▸ | FLT4 | P35916 | 3/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.69 |
| ▸ | STK10 | O94804 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.69 |
| ▸ | BCR | P11274 | 2/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.69 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.69 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.69 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660228 | 0.94 | KDR (0.71) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL1660249 | 0.92 | KDR (0.67) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL1660873 | 0.92 | KDR (0.76) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL1659143 | 0.91 | KDR (0.79) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL5205557 | 0.88 | KDR (0.71) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL5202130 | 0.88 | KDR (0.78) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL1660216 | 0.86 | KDR (0.72) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL5204147 | 0.86 | KDR (0.84) | KDRPDGFRAFLT1FLT4KIT | |
| Hydrochloric Acid SCHEMBL5202398 | 0.85 | KDR (0.82) | KDRPDGFRAFLT1FLT4KIT | |
| SCHEMBL1660426 | 0.85 | KDR (0.82) | KDRPDGFRAFLT1FLT4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |