Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.76 |
| ▸ | PDGFRA | P16234 | 14/20 | 0.68 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | FLT1 | P17948 | 2/20 | 0.66 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.66 |
| ▸ | FLT4 | P35916 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | BCR | P11274 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660228 | 0.92 | KDR (0.71) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL1660282 | 0.92 | KDR (0.71) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL1660249 | 0.88 | KDR (0.67) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL1660246 | 0.88 | KDR (0.74) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL5205557 | 0.86 | KDR (0.71) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL15962876 | 0.84 | KDR (0.69) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL1660426 | 0.84 | KDR (0.82) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL1659143 | 0.84 | KDR (0.79) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL15962761 | 0.84 | KDR (0.79) | KDRPDGFRAKITFLT1EPHB2 | |
| SCHEMBL5204741 | 0.84 | KDR (0.85) | KDRPDGFRAKITFLT1EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |