Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658925 | 0.89 | RAF1 (0.75) | RAF1MEN1KMT2AMAPK1KDR | |
| SCHEMBL1660325 | 0.89 | RAF1 (0.50) | RAF1MAPTGAAKDRPDGFRA | |
| SCHEMBL1661121 | 0.88 | RAF1 (0.61) | RAF1MEN1MAPTKMT2AKDR | |
| SCHEMBL1658903 | 0.88 | RAF1 (0.54) | RAF1MEN1KMT2AMAPK1KDR | |
| SCHEMBL1662348 | 0.86 | RAF1 (0.58) | RAF1KDREPHX2BRAF | |
| SCHEMBL1660163 | 0.86 | RAF1 (0.66) | RAF1MEN1MAPTKMT2AMAPK1 | |
| SCHEMBL1396099 | 0.86 | RAF1 (0.82) | RAF1KDREPHX2BRAF | |
| SCHEMBL5569138 | 0.82 | RAF1 (0.73) | RAF1MEN1KMT2AMAPK1KDR | |
| SCHEMBL1660161 | 0.79 | RAF1 (0.63) | RAF1MEN1KMT2AMAPK1KDR | |
| SCHEMBL1660353 | 0.78 | RAF1 (0.63) | RAF1KDRPDGFRAEPHX2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |