Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.58 |
| ▸ | KDR | P35968 | 14/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659070 | 0.91 | MAPK14 (0.53) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1659083 | 0.89 | RAF1 (0.64) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1660279 | 0.88 | RAF1 (0.66) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1660163 | 0.88 | RAF1 (0.66) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1662296 | 0.86 | RAF1 (0.64) | RAF1KDRBRAF | |
| SCHEMBL1660423 | 0.86 | RAF1 (0.61) | RAF1KDRBRAFEPHX2 | |
| SCHEMBL1658903 | 0.85 | RAF1 (0.54) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1661150 | 0.82 | MAPK14 (0.58) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1660325 | 0.81 | RAF1 (0.50) | RAF1KDRFLT1BRAFEPHX2 | |
| SCHEMBL1660245 | 0.79 | RAF1 (0.68) | RAF1KDRFLT1BRAFEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |