Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.55 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.47 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931366 | 0.86 | ALDH1A1 (0.47) | HSP90AB1HSP90AA1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14305420 | 0.83 | HSP90AA1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL4566903 | 0.83 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL16772876 | 0.83 | ALDH1A1 (0.43) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL8931341 | 0.82 | KDM4E (0.60) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL14293449 | 0.78 | KDM4E (0.43) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL4566884 | 0.77 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL14029952 | 0.75 | HSP90AA1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL14029777 | 0.75 | HSP90AA1 (0.63) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 | |
| SCHEMBL8931367 | 0.75 | HSP90AB1 (0.60) | HSP90AB1HSP90AA1HSP90B1TRAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150150851-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150150851-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150094349-A1 | Method for Treating Proliferative Disorders Associated with Protooncogene Products | SYNTA PHARMACEUTICALS CORP (US) | 2015-04-02 | — | — | US | disclosed |
| US-20150094349-A1 | Method for Treating Proliferative Disorders Associated with Protooncogene Products | SYNTA PHARMACEUTICALS CORP (US) | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094349-A1 | Method for Treating Proliferative Disorders Associated with Protooncogene Products | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AB1 1/4885HSP90AA1 3/4885HSP90B1 7/4885 |
| US-20150150851-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885HSP90AA1 2/4885HSP90B1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.