Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.76 |
| ▸ | RAB9A | P51151 | 9/20 | 0.76 |
| ▸ | PKM | P14618 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675306 | 0.90 | NPC1 (0.72) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL26293792 | 0.89 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL21349103 | 0.89 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL16594545 | 0.89 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL2176413 | 0.89 | NPC1 (0.89) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL17065565 | 0.89 | NPC1 (0.89) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7900640 | 0.88 | NPC1 (0.68) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL14082359 | 0.86 | NPC1 (0.71) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL18216806 | 0.86 | NPC1 (0.67) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL21911449 | 0.86 | KDM4E (0.58) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624224-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-04-18 | — | — | US | disclosed |
| US-20170050970-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20150094319-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050970-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | NPC1 4476/4885RAB9A 2689/4885PKM 3564/4885 |
| US-20150094319-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | NPC1 4476/4885RAB9A 2689/4885PKM 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.