Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.73 |
| ▸ | AXL | P30530 | 3/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | SRC | P12931 | 2/20 | 0.73 |
| ▸ | FER | P16591 | 2/20 | 0.73 |
| ▸ | CDK8 | P49336 | 2/20 | 0.73 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.73 |
| ▸ | MERTK | Q12866 | 2/20 | 0.73 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.73 |
| ▸ | FLT3 | P36888 | 4/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | STK25 | O00506 | 1/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167615 | 0.96 | MET (0.80) | METAXLAURKAABL1LCK | |
| SCHEMBL703248 | 0.91 | MET (0.70) | METAXLAURKAABL1LCK | |
| SCHEMBL168548 | 0.90 | MET (0.82) | METAXLAURKAABL1LCK | |
| SCHEMBL697226 | 0.90 | MET (0.70) | METAXLAURKAABL1LCK | |
| SCHEMBL697732 | 0.90 | MET (0.81) | METAXLAURKAABL1LCK | |
| SCHEMBL166912 | 0.88 | MET (0.75) | METAXLAURKAABL1LCK | |
| SCHEMBL698578 | 0.86 | MET (0.90) | METAXLAURKAABL1LCK | |
| SCHEMBL30471302 | 0.86 | MET (1.00) | METAXLAURKAABL1LCK | |
| SCHEMBL29393648 | 0.86 | MET (1.00) | METAXLAURKAABL1LCK | |
| SCHEMBL167963 | 0.86 | MET (1.00) | METAXLAURKAABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999982-B2 | Pharmaceutically active compounds as Axl inhibitors | LEAD DISCOVERY CENTER GMBH (DE) | 2015-04-07 | — | — | US | claimed |