Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113879 | 0.82 | YTHDC1 (0.37) | PIK3CADRD1YTHDC1NPC1RAB9A | |
| SCHEMBL3099983 | 0.82 | PIK3CA (0.46) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14296957 | 0.71 | YTHDC1 (0.47) | YTHDC1NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL168592 | 0.66 | PIK3CA (0.46) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL113886 | 0.66 | YTHDC1 (0.39) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL116967 | 0.66 | PIK3CA (0.53) | PIK3CA | |
| SCHEMBL114425 | 0.65 | YTHDC1 (0.40) | YTHDC1NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL117532 | 0.65 | PIK3CA (0.51) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL115200 | 0.64 | YTHDC1 (0.48) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL165036 | 0.64 | YTHDC1 (0.43) | PIK3CAYTHDC1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |