Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 8/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606908 | 0.87 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606875 | 0.87 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606919 | 0.87 | JAK1 (0.51) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606904 | 0.85 | JAK1 (0.52) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606950 | 0.85 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606917 | 0.84 | SYK (0.51) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606971 | 0.83 | JAK1 (0.50) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606955 | 0.81 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606881 | 0.81 | IGF1R (0.53) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606956 | 0.80 | SYK (0.47) | JAK1JAK3SYKJAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047124-A1 | NOVEL CHEMICAL COMPOUNDS DERIVED FROM 2,4-DIAMINO-1,3,5-TRIAZINE FOR THE PROPHYLAXIS AND TREATMENT OF HUMAN AND ANIMAL DISEASES | Общество с ограниченной ответственностью "Молекулярные Технологии" | 2015-04-02 | — | — | WO | disclosed |