Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 9/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 2/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606882 | 0.85 | JAK1 (0.51) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606919 | 0.85 | JAK1 (0.51) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606955 | 0.84 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606875 | 0.84 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606908 | 0.84 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606950 | 0.84 | JAK1 (0.49) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606917 | 0.83 | SYK (0.51) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606971 | 0.82 | JAK1 (0.50) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL16606881 | 0.80 | IGF1R (0.53) | JAK1JAK3SYKJAK2EGFR | |
| SCHEMBL656721 | 0.80 | SYK (0.56) | JAK1JAK3SYKJAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047124-A1 | NOVEL CHEMICAL COMPOUNDS DERIVED FROM 2,4-DIAMINO-1,3,5-TRIAZINE FOR THE PROPHYLAXIS AND TREATMENT OF HUMAN AND ANIMAL DISEASES | Общество с ограниченной ответственностью "Молекулярные Технологии" | 2015-04-02 | — | — | WO | disclosed |