Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730052 | 0.90 | SYK (0.47) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL2716612 | 0.90 | SYK (0.47) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL2716301 | 0.76 | SYK (0.46) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL2719063 | 0.70 | SYK (0.58) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL10271837 | 0.70 | SYK (0.46) | SYK | |
| SCHEMBL2716075 | 0.70 | SYK (0.46) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL2716073 | 0.70 | SYK (0.46) | SYKMAPTKMT2AMEN1KDM4E | |
| SCHEMBL2728622 | 0.70 | SYK (0.44) | SYK | |
| SCHEMBL2728618 | 0.70 | SYK (0.44) | SYK | |
| SCHEMBL2730053 | 0.69 | SYK (0.44) | SYKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094298-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094298-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | SYK 1/4885MAPT 1178/4885KMT2A 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.