Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716612 | 1.00 | SYK (0.47) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL16607813 | 0.90 | SYK (0.39) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2716301 | 0.85 | SYK (0.46) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2719063 | 0.80 | SYK (0.58) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2716075 | 0.79 | SYK (0.46) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2716073 | 0.79 | SYK (0.46) | SYKMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2728618 | 0.79 | SYK (0.44) | SYK | |
| SCHEMBL2728622 | 0.79 | SYK (0.44) | SYK | |
| SCHEMBL10271837 | 0.77 | SYK (0.46) | SYK | |
| SCHEMBL10272085 | 0.76 | LMNA (0.43) | SYKMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |